The current place of urea kinetic modelling with respect to different dialysis modalities.

urea, it is rational to assume backdiffusion of such The range of dialysis treatment schedules is rapidly toxic solutes along the nephron similar to that of urea increasing, with renewed interest in daily haemodialysis [3], and hence reasonable to choose Kr as the renal (HD), continuous ambulatory peritoneal dialysis function reference standard for assessing the dose (CAPD), automated peritoneal dialysis (APD), APD of dialysis. combined with CAPD, and HD combined with It is necessary to go back some 50 years to find the CAPD. A scale has not been developed previously for major studies of renal urea clearance. The dependence uniform measurement and comparison of the dialysis of Kr on urine flow rate (Qu) was modelled by Dole doses provided by this broad range of therapies. The in 1943 [4] as a function of GFR, tubular area, purpose of this communication is to report a model permeability to urea and urine flow rate. These relawhich can be used uniformly to measure and thus tionships were studied in humans by Chassis et al. [5]. explicitly compare the doses of dialysis provided by The theoretical Dole equation constants were fit to any combination of intermittent and continuous diahuman data of Chassis et al. by Homer Smith [6 ], lysis treatments. In the development which follows, resulting in these therapies will be analysed with respect to low